The demyelination of central nervous system (CNS) nerves characterizes a chronic condition known as multiple sclerosis (MS). The illness causes a progressive loss of capacity for day-to-day functioning. Patients with MS might exhibit a wide range of symptoms, such as exhaustion, difficulties with motor function, and abnormalities related to the mind and senses. Although these symptoms may manifest at different times, they frequently interact with one another. This necessitates the necessity for MS treatment to be dynamic at every stage of the disease. Given that there is no definitive cure for MS, disease management is achieved through pharmacological treatment, psychological counselling, and physiotherapy strategies. In this disease management process, physiotherapy plays a role in regaining and maintaining functionality, achieving and maintaining independence in activities of daily living, and maintaining and improving cognitive and social functions. MS often exhibits a variable progression, necessitating the implementation of a variable, combined rehabilitation program rather than a standard course of physiotherapy. MS physiotherapy approaches are based on several key issues, including balance, gait, speech, cognitive function, respiration, and occupational therapy. However, physiotherapy approaches are also changing and developing, considering the increasing incidence of MS, increasing life expectancy, and changes in life expectancy. Therefore, this chapter discusses the most current physiotherapy approaches applied to the MS population.