People with disabilities face multiple challenges that become even more severe when their disability intersects with other socially disadvantaged identities, including gender. Women and girls with disabilities face unique challenges due to their disability that intersects with their other social identities. These challenges are particularly evident in the healthcare settings, where they were found to experience barriers to access and support. These women and girls are also affected by the norms around femininity that influence the way they see themselves and are seen by others. Men and boys also experience challenges due to their multiple intersecting social identities and are affected by norms around masculinity around strength, emotional restraint, and independence. These people are socialized through these masculine and feminine norms, which are created and perpetuated within communities and other social institutions. This entry explores ways gender-based inequalities and disability intersect to shape the life experiences of people with disabilities and provides implications for social work practice. Using an intersectional and gender lens, this entry introduces some of the ways women, men, girls, and boys experience their disabilities, consequently shaping their lives. It emphasizes the crucial role social workers play in identifying and addressing systemic barriers faced by these people. The multiple and overlapping issues faced by these diverse groups of people with disabilities are often overlooked in broader discourse within countries and their policies. It further provides implications for social work advocacies and practices for more gender- and socially responsive services for people with disabilities across communities.