Rarefying Osteopathies
摘要
Osteopenia is characterized by reduced bone production or increased bone resorption. This group includes the various forms of osteogenesis imperfecta that can be recognized by prenatal diagnosis. Type 2 presents reduced cranial ossification associated with bone fractures while the other types can be suspected if a “curved” femur or other long bone is observed. The differential diagnosis must be made with early hypophosphatasia, which is a phosphorus-calcium dysmetabolism characterized by reduced generalized ossification.