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Hypertension remains an unsolved public health and socioeconomic problem (Deussen A, Kopaliani I, Curr Opin Nephrol Hypertens 32:111–117, 2023). There are multifactorial etiological processes of hypertension currently under investigation (Deussen A, Kopaliani I, Curr Opin Nephrol Hypertens 32:111–117, 2023). It may be possible to reduce risk factors and prevent the development of hypertension through dietary supplementation and food choices. Current guidelines proposing several interventions to counter the underlying pathophysiology of hypertension include the reduction of salt and alcohol intake, increased potassium intake, exercise, weight loss, and a healthy diet (Whelton PK, Carey RM, Aronow WS, Casey DE, Collins KJ, J Am Coll Cardiol 71:e127–e248, 2017). Although celery and its components, including celery juice, are not a constituent of the aforementioned interventions, they contain several biochemically active compounds which play an important role as antagonists in the development of hypertension, including flavonoids, 3-n-butylphthalide, and sedanolide. Apium graveolens, known commonly as celery, is a plant frequently used as a medical adjunct in the treatment of several conditions, including hypertension, in both traditional and alternative medicine (Fazal SS, Singla R, Indo Global J Pharmaceut Sci 2:36–42, 2012). Celery contains a substantial amount of vitamins and minerals, in particular potassium, fiber, and anti-inflammatory chemicals, which play a role in the interference of various mechanisms that potentiate the development of hypertension (Ernst E, Wien Med Wochenschr 155:386–391, 2005). Both animal studies and those including human subjects support a possible future pharmacotherapeutic role for the medical use of celery and its extracts, including celery juice, for the treatment of hypertension and other cardiovascular diseases (Sheng X, Hua K, Yang C, Wang X, Ji H et al. Bioorg Med Chem Lett 25(17):3535–3540, 2015; Whelton PK, Carey RM, Aronow WS, Casey DE Jr, Collins KJ et al. J Am Coll Cardiol 71:e127–e248, 2017).

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The Influence of Celery (Apium graveolens) Juice on Hypertension

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  • 发表日期：

    2025年

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  • Jennifer Illes,
  • Juliana Rodrigues

摘要

Hypertension remains an unsolved public health and socioeconomic problem (Deussen A, Kopaliani I, Curr Opin Nephrol Hypertens 32:111–117, 2023). There are multifactorial etiological processes of hypertension currently under investigation (Deussen A, Kopaliani I, Curr Opin Nephrol Hypertens 32:111–117, 2023). It may be possible to reduce risk factors and prevent the development of hypertension through dietary supplementation and food choices. Current guidelines proposing several interventions to counter the underlying pathophysiology of hypertension include the reduction of salt and alcohol intake, increased potassium intake, exercise, weight loss, and a healthy diet (Whelton PK, Carey RM, Aronow WS, Casey DE, Collins KJ, J Am Coll Cardiol 71:e127–e248, 2017). Although celery and its components, including celery juice, are not a constituent of the aforementioned interventions, they contain several biochemically active compounds which play an important role as antagonists in the development of hypertension, including flavonoids, 3-n-butylphthalide, and sedanolide. Apium graveolens, known commonly as celery, is a plant frequently used as a medical adjunct in the treatment of several conditions, including hypertension, in both traditional and alternative medicine (Fazal SS, Singla R, Indo Global J Pharmaceut Sci 2:36–42, 2012). Celery contains a substantial amount of vitamins and minerals, in particular potassium, fiber, and anti-inflammatory chemicals, which play a role in the interference of various mechanisms that potentiate the development of hypertension (Ernst E, Wien Med Wochenschr 155:386–391, 2005). Both animal studies and those including human subjects support a possible future pharmacotherapeutic role for the medical use of celery and its extracts, including celery juice, for the treatment of hypertension and other cardiovascular diseases (Sheng X, Hua K, Yang C, Wang X, Ji H et al. Bioorg Med Chem Lett 25(17):3535–3540, 2015; Whelton PK, Carey RM, Aronow WS, Casey DE Jr, Collins KJ et al. J Am Coll Cardiol 71:e127–e248, 2017).