Peripheral Nervous System

One generally has to distinguish between surface anesthesia, infiltration anesthesia, and conduction anesthesia (Fromherz, Naunyn-Schmiedeberg’s Arch Exp Pathol Pharmakol 93:72–91, 1922; Schaumann, Naunyn-Schmiedeberg’s Arch Exp Pathol Pharmakol 190:30–51, 1938; Camougis and Takman, Nerve and nerve-muscle preparations (as applied to local anesthetics). In: Schwartz A (ed) Methods in pharmacology, vol 1. Appleton-Century-Crofts. Educational Division, Meredith Corp, New York, pp 1–40, 1971). Special local tolerance tests have been developed for each of these applications including peridural and intrathecal injections.