Physicochemical Properties of Drugs for Use in the Pharmaceutical Industry

This chapter provides a description of the three central elements in the physicochemical characterization of drug compounds, i.e., the acid dissociation constant, log P, and solubility, and the associated experiment to determine the solid form, in particular, for the latter property. The description of the different properties includes both a description of the concrete property and a short explanation of its importance and a description of the main experimental methods to determine the parameter under discussion. The designated three main properties are selected, as these are highly important in order to understand the druggability of a novel compound; hence, they are important optimization parameters for a novel compound.