Synthesis and Evaluation of Some Fused Ring System of Thiazole for Their Antimicrobial Activity

A series of novel N-2 [2-chloro-4(3,4,5-trimethoxy phenyl azetidine-1-yl)-N4(substituted aryl)-1,3-thiazole-2,4-diamine(4a-j) werw synthesized starting from 3,4,5-trimethoxy benzaldehyde thiaosemicarbazone(1). the compound (1) was obtained by condensing 3,4,5-trmethoxy benzaldehyde with thiosemicarabzide in methanol. 3,4,5-trimethoxy benzaldehyde thiaosemicarbazone(1) on treatment with chloroacetyl chloride afforded 4-chloro [2-(3,4,5-trimethoxy benzylidine) hydrazinyl]-1,3-thiazole(2). Compound 2 was reacted with chloroacetyl chloride and trethylamine to obtain the corresponding 4-chloro-N[2-chloro-4(3,4,5-trimethoxy phenyl)azetidine-1-yl]-1,3-thiazole-2-amine(3). Various substitution on compound(3) with secondary amines yielded series of compounds (4a-j). The newly synthesized compounds were characterized by IR, 1H NMR, Elemental analysis and Mass spectral studies. All the compounds were screened for their antimicrobial properties. Disc diffusion values of compound 3 and 4(a-j) revealed that the some of synthesized compounds were showing potent antibacterial activity.