Evaluation of Ondansetron Hydrochloride Interactions with Mannitol

The present study is to evaluate Ondansetron Hydrochloride (OND) interaction with Mannitol. Attempt has been made to prepare physical mixtures of OND with Mannitolin different proportions. The mixture was subjected to room temperature and accelerated temperature as per ICH guideline 1996. The interaction was studied by IR, UV Absorbance, TLC, Dissolution and DSC. From the study it was clear that C = O is the major site for interaction and more interaction is observed in case of accelerated condition than the room temperature. From the data obtained, it is observed that Mannitol showed the interaction with OND Mannitol cause significant reduction in dissolution of OND.