Food and nutrition security continues to be a global challenge. This may be from an inability to leverage culture as an integral lever to translate global frameworks into local systems. Cultural value orientations, such as individualism-collectivism, can profoundly influence the conceptualization of food and health systems and practices. It can be argued that food, nutrition, and food and nutrition security concepts and measuring tools have evolved from individualist, neoliberal, and biomedical values and thus largely ignore diverse cultural understandings of food and health systems and practices. Individualist-orientated cultures predominantly approach health biomedically, where food is valued for its nutrient content. Collectivist-orientated cultures mostly see a continuity between themselves and the environment, where consuming foods is a spiritual enactment connecting the physical body with land, nature, history, and community. In recent decades, individualist values and thinking have predominated creating global food systems that undermine more collectivist food systems approaches. To address food and insecurity, it will be essential to reconceptualize food and nutrition security so that it integrates collectivist ways of thinking, being, and knowing.