The COVID-19 Pandemic and the Mediterranean Diet
摘要
The COVID-19 pandemic has profoundly impacted health and lifestyle habits globally, emphasizing the critical role of dietary patterns that support immune function and metabolic health. Characterized by high consumption of fruits, vegetables, legumes, nuts, olive oil, fish, and moderate intake of red wine, the Mediterranean diet (MedDiet) is rich in polyphenols, omega-3 fatty acids, dietary fiber, and essential vitamins and minerals. These components collectively contribute to its anti-inflammatory, antioxidant, and immune-supportive properties. The MedDiet adherence can reduce the expression of pro-inflammatory molecules such as tumor necrosis factor-alpha, interleukin-1, interleukin-6, and C-reactive protein, thereby mitigating systemic inflammation. It is also suggested to exert antiviral effects by reducing the expression of nuclear transcription factor kappa B. Moreover, the essential elements of the MedDiet act as antioxidants, protecting cellular integrity by attenuating the effects of reactive oxygen species produced by immune cells. These nutrients further support gut microbiota, strengthen epithelial barrier function, and activate polymorphonuclear and natural killer cells to produce antimicrobial peptides, collectively reducing infection risk and facilitating viral clearance. Research has demonstrated that adherence to the MedDiet can reduce systemic inflammation, modulate gut microbiota, enhance immune resilience, and improve health markers such as lipid profiles, glycemic control, and blood pressure, all of which are critical in mitigating COVID-19 severity. Such findings have heightened interest in the potential protective role of the MedDiet against COVID-19, highlighting its importance in supporting health during pandemics. By combining its protective impacts against severe health outcomes, its ability to promote physical and psychological well-being, and its effect on sustainability, the MedDiet offers a holistic approach to improving public health. These attributes establish its significance not only in pandemic response but also as a foundation for enhancing resilience against future health crises.