This chapter explores the rapid changes in the Arctic region due to climate change, specifically through the lens of Arctic Amplification, which results in significantly higher temperature increases than the global average. It focuses on the severe impacts faced by Indigenous communities, particularly Alaska Natives, whose traditional lifestyles are increasingly threatened. The melting sea ice leads to the loss of vital hunting grounds, jeopardizing their cultural practices and economic stability. Additionally, key species are losing their habitats, while coastal erosion poses a risk to their homes. This chapter emphasizes the intersection of climate change and human rights, underscoring the urgent need for collective action to safeguard this vulnerable region’s cultural heritage and environment.