Dominant, Lesional Post-Traumatic Temporal Lobe Epilepsy

This chapter discusses a patient with pharmacoresistant post-traumatic epilepsy undergoing intracranial monitoring to characterize areas of ictal onset and guide resection. The stages of epileptogenesis in patients with traumatic brain injury are summarized, as well as the critical role of neuroimaging modalities in determining the extent of cerebral injury. We discuss surgical outcomes in this patient population, surgical interventions available, and predictors of outcome. We explain the risks of intracranial monitoring in this patient population. We stress the importance of medication adherence following resective surgery. Furthermore, we enumerate tools for improving medication compliance, including novel technological tools such as gamification. Additionally, we examine the significance of gliosis in the histopathological analyses of patients with epilepsy. Finally, we discuss semiologies including déjà vu, visual phenomena, and unilateral tonic seizures.