Non-dominant, Non-lesional Mesial Temporal Lobe Epilepsy

This chapter presents a patient with MRI-negative and PET-positive pharmacoresistant temporal lobe epilepsy. We review the surgical outcomes and determinants of favorable post-operative results in patients with MRI-negative temporal lobe epilepsy. We discuss the utility of interictal PET scan in patients with non-lesional temporal and extra-temporal pharmacoresistant epilepsies. We shed light on the significance of the ictal propagation latency in temporal lobe epilepsy and its relation to surgical outcomes. We address the significance of ictal slow wave activity in the fronto-parietal cortices during temporal lobe seizures with impaired awareness. Finally, we examine semiologies such as ictal grasping, hypermotor symptoms, ictal spasms, and laryngeal and respiratory manifestations.