Metabolomics: Metabolite Changes in Response to Cold Stress with a Special Focus on Whole-body Cryostimulation

Metabolomics is a powerful tool that encompasses the complete set of metabolites involved in various metabolic pathways, providing valuable insights into an organism’s physiological status. The external environment plays a crucial role in shaping the metabolome of living organisms. Metabolomics is particularly useful for investigating how external factors, such as diet, lifestyle, drugs, thermal stress, and other environmental exposures, can influence an individual’s metabolic profile and overall health. When an organism experiences thermal stress, its metabolic pathways can be altered to maintain homeostasis, repair damage, and ensure survival. This chapter highlights the role of metabolomics in identifying metabolites involved in the response to thermal stress, as well as reviews specific metabolic pathways affected by cold stress and the underlying physiological responses mediated by cold.