This chapter discusses a case study that will examine the use of geospatially integrated Habitat Suitability Models (HSM) to explore the role of place in the context of wetland mitigation and management efforts. Wetlands are critical resources and represent an ideal case study for coupled and complex natural and human systems and have spatial dimensions as wetland typology is implicitly tied to place, inland, or coastal. To minimize wetland loss due to urban and economic development, the US Government instituted a ‘no net loss’ policy with an overall goal of wetland preservation (in terms of acreage-per-acreage replacements) by creating and restoring wetlands that are referred to as ‘mitigated wetlands.’ While both coastal and inland wetlands provide valuable ecological services, their functions and services are not identical; hence remedy for the destruction or disturbance of coastal wetlands cannot be achieved by creating inland wetlands somewhere within the state boundaries. Any mitigation and replacement for wetlands should be ‘type for type’ to ensure the functions and benefits of particular wetlands are not lost in the process. Thus, a universal wetland assessment method (including clearly identified functionality of each wetland type) is needed to guide wetland mitigation efforts and decision-making processes. This is where a place-based system approach using an integrated geospatial framework can be useful. A spatially integrated EDST can identify landscapes with ideal environmental conditions for future mitigation wetland sites during the permitting process to facilitate type-for-type and functional replacements of wetlands (not acreage alone) to ensure the success of mitigation sites.