Bridging the Gap: Nanotechnology’s Impact on Neuroscience—A Systematic Review of Clinical Trial

Nano-neurotechnology, also known as NanoNeuro, is an exciting and emerging field that combines nanotechnology and neuroscience to repair and manipulate damaged neural circuits at the atomic, cellular, or molecular levels. This field has great potential to offer noninvasive therapeutics and diagnostics with enhanced efficacy for neurological diseases. Understanding the clinical status of NanoNeuro technology can help us gain a comprehensive view of the subject, which is important for making policy decisions and predicting technology trends and market in the field of neuroscience. To investigate the status of clinical trials that address the technologies that can reach clinical grade, we conducted a systematic search on this topic using valid databases. Describing and analyzing data from clinical studies can help us identify which nano-technologies have superior effects and can pass experimental studies. Additionally, we can determine which countries are pioneering in the field of nano-technology. For this research, we used the PRISMA guideline to search the Web of Science, PubMed, Embase, and Scopus databases. Two independent authors selected relevant articles and extracted data. We included 41 articles in this review, with the most active countries being Iran, Germany, and France. The trend of publication has been increasing since 2014, with the highest number of publications in 2021 (n = 9). Among the included clinical trials, episodic migraine was the most commonly studied disease, accounting for 30% of all trials (n = 12). Multiple sclerosis and glioblastoma followed closely with five trials each. The most frequently used nanodrug in the studies was nanocurcumin (n = 18), and most of the studies were funded by national sources. In summary, this systematic review provides an overview of the current status of nanotechnology in neurological diseases. The findings suggest that NanoNeuro has the potential to offer novel and effective treatments for various neurological disorders. Further research is needed to fully explore the potential of nanotechnology in improving neurological health.