Nanostructured Surfaces for Intracerebral Neurotransmitter Recording
摘要
Nanotechnology is a growing cross between biomedical engineering and medicine. Thanks to the size of the biomolecules, nanoparticles allow us to navigate uncharted territories by mapping parts of the brain and tracking neurotransmitter activity for a better understanding of neurobiological systems. One of the challenges of these studies is finding the appropriate materials, small enough to enter the brain parenchyma and record its activity without harming it. Since the 1980s, a long series of scientific investigations began by seeing the atom for the first time and eventually led to the creation of neural probes capable of withstanding electrochemical degradation and delamination, therefore introducing more durability to these inventions (Vidu et al., Front Syst Neurosci 8:91, 2014). This chapter will cover the different materials and methods for intracerebral neurotransmitter measurements as well as the nanostructure of microelectrode array recording sites.