Adipose tissues—the plural is essential due to the heterogeneity of this assorted group of tissues—are no longer simply considered as an energy storage compartment. Indeed, they play a major role in controlling body composition, appetite, metabolism, inflammation, and many other physiological processes, including reproduction, bone health, immune response, and mood modulation. A variety of highly prevalent diseases, from obesity and metabolic disease, extending to cancer cachexia and COVID-19, involve a dysregulation of the adipose tissue, often related with its capacity to release inflammatory factors. Fat cells produce hormones strictu sensu, namely, leptin and adiponectin, but also a plethora of factors collectively known as atable dipokines (or lipokines) and miRNAs that target multiple tissues and organs. It is evident that understanding and, subsequently, enabling adipose tissue activity modulation are matters of life or death. The current view of adipose tissue as a fundamental endocrine organ places this tissue at the righteous, central position it deserves in the control of our well-being, which is dependent on extensive organ-tissue crosstalk.