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Medically ill hospitalized patients are a high-risk group for the development of deep vein thrombosis and or pulmonary embolism. Risk assessment modules such as the Padua, IMPROVE and IMPROVEDD were validated in order to identify patients who would benefit from prophylactic anticoagulation. In addition, the IMPROVE Bleeding Risk Score was validated to predict the risk of major bleeding. These tools were part of studies evaluating various pharmacologic anticoagulants to prevent Deep Vein Thrombosis and Pulmonary Embolism (DVT/PE) in this patient population. This chapter will review the VTE and major bleeding risk tools as well as the major studies assessing low molecular weight heparins and direct oral anticoagulants with respect to efficacy and safety. This chapter will provide the best approach to the management of the high-risk medically ill hospitalized patient.

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Venous Thromboembolism: Risk Assessment and Prophylaxis in the Medically Ill

  • 动态工具书词条

  • 发表日期：

    2025年

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  • John Stewart,
  • Lily Ackermann,
  • Geno J. Merli,
  • Alex C. Spyropoulos

摘要

Medically ill hospitalized patients are a high-risk group for the development of deep vein thrombosis and or pulmonary embolism. Risk assessment modules such as the Padua, IMPROVE and IMPROVEDD were validated in order to identify patients who would benefit from prophylactic anticoagulation. In addition, the IMPROVE Bleeding Risk Score was validated to predict the risk of major bleeding. These tools were part of studies evaluating various pharmacologic anticoagulants to prevent Deep Vein Thrombosis and Pulmonary Embolism (DVT/PE) in this patient population. This chapter will review the VTE and major bleeding risk tools as well as the major studies assessing low molecular weight heparins and direct oral anticoagulants with respect to efficacy and safety. This chapter will provide the best approach to the management of the high-risk medically ill hospitalized patient.