The resistance to LGBTQ+ is very strong in Africa, particularly in Nigeria and Uganda—these two nations have criminalized LGBTQ+ practices, and merely advocating for such rights is considered a crime. This chapter unpacks the complexities of LGBTQ+ issues in Africa by tracing the causes of homophobia at both the individual and state levels and other factors such as religious beliefs, neocolonialism, ideological perspective, cultural imposition, and dominance. The chapter juxtaposes the human rights perspective, which advocates for decriminalization, legalization, and recognition of sexual minorities, and the view of African conservatives as a global north cultural imposition capable of eroding African norms and values. The chapter draws attention to the plights of members of LGBTQ+ in heterosexist and homophobic African states, such as widespread discrimination, stigmatization, violence, and severe penalties, with death sentences, in nations like Sudan and Mauritania. Despite progress in countries like South Africa, Botswana, and Mozambique, where constitutional protections and decriminalization have advanced, homophobia remains pervasive in many African societies. To address these complexities, the chapter suggests a balanced approach in the debate between Western extreme liberals and African conservatives, advocating for dialogue that respects African cultural and religious contexts while promoting human rights. This could foster gradual acceptance, reduce stigma, and encourage decriminalization, acknowledging both local values and global norms.