Commercial data centers are large-scale and purpose-built facilities that are often operated by “hyperscalers” and support cloud computing and artificial intelligence. Such data centers typically use water for cooling and are characterized by a high consumption of electricity that can be supplied from multiple sources. This is to ensure high reliability and redundancy. However, there are also growing concerns about their contribution to climate change and impacts on water resources. This chapter summarizes the current approaches to address these issues through sustainable energy management and cooling practices, as well as architectural and structural design solutions for the data center buildings. When available, life-cycle data have been used to support conclusions being made.