Amputation is an ancient surgical intervention that is still necessary for patients whose limbs are nonviable or seriously diseased, usually as a result of severe vascular disease, trauma, or cancer. Diabetes mellitus and peripheral vascular disease are the two main indications for lower-extremity amputations, which still account for the great majority of occurrences despite advancements in limb-salvage techniques. From the evaluation of postoperative anatomy and prosthesis fit to the early identification of problems, accurate imaging evaluation of the residual limb is essential throughout the care continuum. This chapter provides a comprehensive overview of the imaging evaluation of the residual limb following amputation. Numerous techniques, such as computed tomography, magnetic resonance imaging, positron emission tomography, radiography, and ultrasound, each have special benefits for detecting issues such as adventitious bursae, soft tissue infection, osteomyelitis, neuromas, and osseous overgrowth. Surgical decisions, prosthetic modifications, and rehabilitation techniques are guided by imaging findings that accurately characterise residual limb anatomy and probable sources of pain or dysfunction. As a result, radiologists play a crucial role in helping amputees achieve their best possible outcomes by providing timely and focused interventions that encourage recovery, increase mobility, and enhance quality of life.