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Wound healing is a complex, multifactorial process that is divided in sequential and overlapping phases in order to restore the skin barrier. For the study of wound healing, different in vivo, in vitro, and ex vivo models have been used in the past. Here, we describe in detail the methodology of the human skin punch-in-a-punch ex vivo wound healing model.

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Human Wound Healing Ex Vivo Model with Focus on Molecular Markers

  • 实验方案

  • 发表日期：

    2026年

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  • Ilaria Piccini,
  • Janin Edelkamp,
  • Marta Bertolini

摘要

Wound healing is a complex, multifactorial process that is divided in sequential and overlapping phases in order to restore the skin barrier. For the study of wound healing, different in vivo, in vitro, and ex vivo models have been used in the past. Here, we describe in detail the methodology of the human skin punch-in-a-punch ex vivo wound healing model.