Alternative treatment medicines are urgently needed as demonstrated by an increase in drug-resistant viral strains and the increasing prevalence of viral infections. This study focuses on the antiviral properties of specific leaf extracts from medicinal plants against specific viral infections. Aqueous ethanolic and methanol solvents of different intensities have been utilized to extract leaves from commonly utilized medicinal plants after they had been shade-dried. To find bioactive substances such as flavonoids, alkaloids, tannins, and saponins, the phytochemical composition of the extracts was first screened. Appropriate cell lines and viral strains were used in in vitro antiviral tests such as cytopathic effect (CPE) inhibition and plaque reduction assays. According to the results, particular leaf extracts showed strong antiviral activity, which was probably related to the presence of secondary metabolites that are known to inhibit viral entrance, replication, or assembly. As a natural source of antiviral medicines, these results suggest that plant-derived leaf extracts have potential and should be investigated further using compound isolation and mechanistic research.