Fluorescence in situ hybridization (FISH) can be performed in many different ways and involves wet lab work, microscopy, and interpretation of the results. Accordingly, a fully automated system for FISH is practically unfeasible. However, it is possible to automate individual steps of the FISH procedure, such as sample preparation, denaturation, washing after hybridization, and preliminary microscopic evaluation of the slides. The interpretation of the results can only be automated with caution, as unexpected deviations from the expected results can always occur.