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In addition to in vitro approaches that use intestinal or liver cells in culture, ex vivo approaches represent a valuable model for evaluating the gastrointestinal toxicity of food contaminants. This chapter provides a comprehensive description of the preparation of punch-excised intestinal explants and precision-cut intestinal or liver slices. It illustrates the application of these techniques to the toxicity of mycotoxins, natural contaminants that are very prevalent in food and feed. These toxins are produced by toxigenic filamentous fungi, predominantly belonging to the genera Aspergillus, Fusarium, and Penicillium.

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Porcine Explants and Slices: Original Models to Analyze the Effects of Mycotoxins

  • 章节

  • 发表日期：

    2026年

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  • Philippe Pinton,
  • Delphine Payros,
  • Laura Soler-Vasco,
  • Isabelle P. Oswald

摘要

In addition to in vitro approaches that use intestinal or liver cells in culture, ex vivo approaches represent a valuable model for evaluating the gastrointestinal toxicity of food contaminants. This chapter provides a comprehensive description of the preparation of punch-excised intestinal explants and precision-cut intestinal or liver slices. It illustrates the application of these techniques to the toxicity of mycotoxins, natural contaminants that are very prevalent in food and feed. These toxins are produced by toxigenic filamentous fungi, predominantly belonging to the genera Aspergillus, Fusarium, and Penicillium.