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Single-cell whole genome sequencing (WGS) enables accurate identification and characterize circulating tumor cells (CTCs) in blood and non-blood body fluids, leading to a non- or minimally invasive liquid biopsy approach for cancer diagnosis and prognosis. Here, we describe a single-cell low-pass WGS protocol for sensitive and accurate CTCs detection in blood and non-blood body fluids by combining a metabolic function-associated marker and a Tn5 transposome-based WGS method.

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Single-Cell Low-Pass Whole Genome Sequencing of Circulating Tumor Cells

  • 实验方案

  • 发表日期：

    2026年

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  • Zhuo Wang,
  • Qihui Shi

摘要

Single-cell whole genome sequencing (WGS) enables accurate identification and characterize circulating tumor cells (CTCs) in blood and non-blood body fluids, leading to a non- or minimally invasive liquid biopsy approach for cancer diagnosis and prognosis. Here, we describe a single-cell low-pass WGS protocol for sensitive and accurate CTCs detection in blood and non-blood body fluids by combining a metabolic function-associated marker and a Tn5 transposome-based WGS method.