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The determination of experimental X-ray crystal structures of macrophage migration inhibitory factor (MIF) with bound ligands is a crucial step in understanding their binding modes and steering medicinal chemistry efforts. Here, a generic method for the crystallization of MIF and subsequent structural analysis with ligands is described.

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Structural Determination and Ligand Interaction of Macrophage Inhibitory Factor: A Standardized X-Ray Crystallography Approach

  • 实验方案

  • 发表日期：

    2026年

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  • Emmanuel K. Yeboah,
  • Alessandro T. Caputo

摘要

The determination of experimental X-ray crystal structures of macrophage migration inhibitory factor (MIF) with bound ligands is a crucial step in understanding their binding modes and steering medicinal chemistry efforts. Here, a generic method for the crystallization of MIF and subsequent structural analysis with ligands is described.