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Bioconjugation of linker-payloads on monoclonal antibodies is achieved to target the action of a small molecule towards a cell of interest. Herein, the bioconjugation of a vedotin linker-payload to an immunoglobulin G (IgG) is described along with the subsequent analysis of the obtained antibody-drug conjugate (ADC).

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Antibody-Drug Conjugates Synthesis Using Maleimide Chemistry

  • 实验方案

  • 发表日期：

    2026年

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  • Camille Martin,
  • Sreenivasachary Nampally

摘要

Bioconjugation of linker-payloads on monoclonal antibodies is achieved to target the action of a small molecule towards a cell of interest. Herein, the bioconjugation of a vedotin linker-payload to an immunoglobulin G (IgG) is described along with the subsequent analysis of the obtained antibody-drug conjugate (ADC).