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Hydrophobic deep eutectic solvents (HDESs) can serve as pseudostationary phases (PSPs) in capillary electrophoresis (CE). Their integration into conventional chiral CE methodologies, such as cyclodextrin-based electrokinetic chromatography, demonstrates a synergistic effect that notably enhances chiral separation efficiency. This chapter presents an example elucidating the enantioseparation of four azole antifungal drugs (tioconazole, isoconazole, miconazole, and econazole) employing carboxymethyl-β-cyclodextrin and the HDES methyltrioctylammonium chloride-octanoic acid.

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Chiral Separation in Capillary Electrophoresis Using Cyclodextrins in Combination with Hydrophobic Deep Eutectic Solvents

  • 实验方案

  • 发表日期：

    2026年

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  • Qi Zhang,
  • Song Xue,
  • Yu Xu

摘要

Hydrophobic deep eutectic solvents (HDESs) can serve as pseudostationary phases (PSPs) in capillary electrophoresis (CE). Their integration into conventional chiral CE methodologies, such as cyclodextrin-based electrokinetic chromatography, demonstrates a synergistic effect that notably enhances chiral separation efficiency. This chapter presents an example elucidating the enantioseparation of four azole antifungal drugs (tioconazole, isoconazole, miconazole, and econazole) employing carboxymethyl-β-cyclodextrin and the HDES methyltrioctylammonium chloride-octanoic acid.