The healthiest mushrooms for people are thought to be shiitake, cordyceps, reishi, turkey tail, chaga, and maitake. Supplements and medicinal mushrooms are being sold with the promise of promoting heart and brain health as well as preventing cancer. Another name for the chaga mushroom is the “king of medicinal mushrooms.” It may lengthen life because it improves immunity, liver health, and brain function. Lion’s Mane is known for its ability to improve brain health and nervous system function. It is also called the “mushroom of the soul.” It may play a role in preventing diseases such as Parkinson’s and Alzheimer’s. Ganoderma lucidum is also known as the “mushroom of immortality.” It strengthens the immune system, supports sleep, prevents fatigue, and reduces stress. Colorful mushrooms and turkey mushrooms are said to strengthen the immune system and prevent cancer. It also supports the intestines. Shiitake mushroom improves liver function, heart health, and immunity. Cordyceps sinensis mushroom is also called “caterpillar mushroom.” It prevents allergies and supports lung health. Maitake mushroom is called the dancing mushroom. It is known for strengthening the immune system, controlling blood sugar and cholesterol levels, controlling blood pressure, and helping with weight loss. Primary metabolites provide energy, while secondary metabolites have medicinal properties. Therefore, mushrooms can be a good medicine for human health and will play an important role in the fight against infectious diseases. In addition to being excellent natural sources of protein, mushrooms also work wonders as natural immune boosters. Portobello, shiitake, oyster, and cremini mushrooms are all readily available, but lesser-known varieties, such as Shaggy mane, Enoki, Maitake, Reishi, and Lion’s mane, are both tasty and useful for strengthening the immune system.