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High-content screening (HCS), a phenotypic-based approach, leverages cellular assays, automated microscopy, and bioimage analysis to efficiently describe the response of complex biological systems to thousands of individual compounds. Herein, we present a framework for high-throughput academic drug discovery campaigns using HCS methodologies. The workflow covers assay development, screening, data analysis, and hit validation, offering detailed guidance for success.

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High-Content Screening Framework for Academic Early Drug Discovery

  • 实验方案

  • 发表日期：

    2026年

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  • André F. Maia,
  • António Pombinho,
  • Hugo M. Botelho

摘要

High-content screening (HCS), a phenotypic-based approach, leverages cellular assays, automated microscopy, and bioimage analysis to efficiently describe the response of complex biological systems to thousands of individual compounds. Herein, we present a framework for high-throughput academic drug discovery campaigns using HCS methodologies. The workflow covers assay development, screening, data analysis, and hit validation, offering detailed guidance for success.