Scholarlink

Identification of key genes regulating critical cellular functions, such as cancer cell proliferation, invasion, and immune escape, is essential for the development of novel cancer therapeutic targets and patient stratification. Our studies have shown that the expression of the proto-oncogene Bcl3 and the pro-angiogenic chemokine IL-8 is increased in ovarian cancer (OC) tissues and correlates with the expression of immune checkpoint PD-L1, resulting in increased proliferation of OC cells. Here, we describe a protocol to analyze the gene co-expression of Bcl3, IL-8, and PD-L1 by using the Xena platform and show that Bcl3, IL-8, and PD-L1 are co-expressed in glioblastoma as well as in pan-cancer samples.

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Bioinformatics Analysis of Bc3, IL-8, and PD-L1 Gene Co-expression in Glioblastoma and Pan-Cancer Using Xena Platform

  • 实验方案

  • 发表日期：

    2026年

查看全文
  • Suprataptha U. Reddy,
  • Yan Zhu,
  • Ivana Vancurova

摘要

Identification of key genes regulating critical cellular functions, such as cancer cell proliferation, invasion, and immune escape, is essential for the development of novel cancer therapeutic targets and patient stratification. Our studies have shown that the expression of the proto-oncogene Bcl3 and the pro-angiogenic chemokine IL-8 is increased in ovarian cancer (OC) tissues and correlates with the expression of immune checkpoint PD-L1, resulting in increased proliferation of OC cells. Here, we describe a protocol to analyze the gene co-expression of Bcl3, IL-8, and PD-L1 by using the Xena platform and show that Bcl3, IL-8, and PD-L1 are co-expressed in glioblastoma as well as in pan-cancer samples.