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Human fungal pathogens account for ~1.5 million deaths annually across the globe, more than malaria and TB combined, in addition to a significant morbidity cost. Genome sequencing has proved to have a crucial role in the analysis of human fungal pathogens, allowing us to gain insights into their virulence factors, drug resistance mechanisms, and population dynamics. The process of reconstructing (near) complete genomes from fragmented DNA sequence, referred to as genome assembly, plays a pivotal role in modern fungal genomics. This book chapter aims to provide an exploration of genome assembly methods and techniques applied to human fungal pathogens, enabling a deeper understanding of their nature and life histories, yet highlighting the unique challenges within this area.

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Current Approaches in Genome Assembly of Human Fungal Pathogens

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  • 发表日期：

    2025年

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  • Johanna Rhodes

摘要

Human fungal pathogens account for ~1.5 million deaths annually across the globe, more than malaria and TB combined, in addition to a significant morbidity cost. Genome sequencing has proved to have a crucial role in the analysis of human fungal pathogens, allowing us to gain insights into their virulence factors, drug resistance mechanisms, and population dynamics. The process of reconstructing (near) complete genomes from fragmented DNA sequence, referred to as genome assembly, plays a pivotal role in modern fungal genomics. This book chapter aims to provide an exploration of genome assembly methods and techniques applied to human fungal pathogens, enabling a deeper understanding of their nature and life histories, yet highlighting the unique challenges within this area.