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In vitro blood-brain barrier models play a pivotal role in neuroscience research to study the intricate structure and function of the blood-brain barrier, facilitating drug development, enhancing disease understanding, and advancing treatment strategies for neurological disorders. Here, we present a triple contact coculture model with endothelial cells, astrocytes, and pericytes and offer a physiologically relevant BBB.

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A 3D In Vitro Blood-Brain Barrier Model to Study Pathogen and Drug Effects on the BBB

  • 实验方案

  • 发表日期：

    2025年

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  • Alizé Proust,
  • Robert J. Wilkinson

摘要

In vitro blood-brain barrier models play a pivotal role in neuroscience research to study the intricate structure and function of the blood-brain barrier, facilitating drug development, enhancing disease understanding, and advancing treatment strategies for neurological disorders. Here, we present a triple contact coculture model with endothelial cells, astrocytes, and pericytes and offer a physiologically relevant BBB.