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The application of Mendelian randomization (MR) analytical framework based on genome-wide association study (GWAS) datasets has uncovered hundreds of risk factors involving disease development that included tumorigenesis, but the practice of MR in cancer survival remains limited. Here, we will provide abundant details of our previously established tool, SUrvival related cancer Multi-omics database via MEndelian Randomization (SUMMER; http://njmu-edu.cn:3838/SUMMER/ ), which would help users systematically evaluate the causal effects of risk factors and circulating biomarkers on pan-cancer survival.

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SUMMER: A Practical Tool for Identifying Factors and Biomarkers Associated with Pan-cancer Survival

  • 实验方案

  • 发表日期：

    2025年

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  • Junyi Xin,
  • Silu Chen,
  • Huiqin Li,
  • Mulong Du,
  • Meilin Wang

摘要

The application of Mendelian randomization (MR) analytical framework based on genome-wide association study (GWAS) datasets has uncovered hundreds of risk factors involving disease development that included tumorigenesis, but the practice of MR in cancer survival remains limited. Here, we will provide abundant details of our previously established tool, SUrvival related cancer Multi-omics database via MEndelian Randomization (SUMMER; http://njmu-edu.cn:3838/SUMMER/ ), which would help users systematically evaluate the causal effects of risk factors and circulating biomarkers on pan-cancer survival.