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Elastin-like peptides (ELPs) are synthetic, repetitive sequences known for their temperature-dependent reversible self-assembly, making them environmentally friendly, biocompatible, and thermoresponsive. Despite various strategies for ELP production, the development of effective ELP supply methods remains a challenge. This chapter outlines a practical approach to synthesizing thermoresponsive ELPs using liquid-phase peptide synthesis (LPPS) with a hydrophobic benzyl alcohol support (HBA-Tag) and fragment condensation. This method effectively produces short ELPs that exhibit temperature-responsive self-assembly.

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Development of the Efficient Preparation Method for Thermoresponsive Elastin-Like Peptides Using Liquid-Phase Synthesis Combined with Fragment Condensation Strategy

  • 实验方案

  • 发表日期：

    2025年

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  • Keitaro Suyama,
  • Takeru Nose

摘要

Elastin-like peptides (ELPs) are synthetic, repetitive sequences known for their temperature-dependent reversible self-assembly, making them environmentally friendly, biocompatible, and thermoresponsive. Despite various strategies for ELP production, the development of effective ELP supply methods remains a challenge. This chapter outlines a practical approach to synthesizing thermoresponsive ELPs using liquid-phase peptide synthesis (LPPS) with a hydrophobic benzyl alcohol support (HBA-Tag) and fragment condensation. This method effectively produces short ELPs that exhibit temperature-responsive self-assembly.