Scholarlink

Electrode reactions can use electrons as traceless and waste-free redox reagents instead of chemicals. The development of “electrochemical” amide bond formation has enabled a new liquid-phase peptide synthesis without the use of typical coupling reagents. A triphenylphosphine radical cation generated by an electrode reaction activates carboxylic acids by providing phosphonium ions to induce amide bond formation, leading to the synthesis of peptides.

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Liquid-Phase Peptide Synthesis Enabled by Electrochemical Amide Bond Formation

  • 实验方案

  • 发表日期：

    2025年

查看全文
  • Yohei Okada,
  • Shingo Shinjo-Nagahara,
  • Kazuhiro Chiba

摘要

Electrode reactions can use electrons as traceless and waste-free redox reagents instead of chemicals. The development of “electrochemical” amide bond formation has enabled a new liquid-phase peptide synthesis without the use of typical coupling reagents. A triphenylphosphine radical cation generated by an electrode reaction activates carboxylic acids by providing phosphonium ions to induce amide bond formation, leading to the synthesis of peptides.