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Microwave peptide synthesis offers significant advantages for peptide production in speed, efficiency, and overall purity. This chapter surveys key developments including the introduction of a wash-free methodology that has enabled 95% waste reduction in peptide synthesis at both research and production level solid-phase peptide synthesis (SPPS). Microwave SPPS is a widely used technique for R&D scale peptide synthesis with more recent expansion into larger scale current good manufacturing practice (cGMP).

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Ultra-Efficient Solid-Phase Peptide Synthesis

  • 实验方案

  • 发表日期：

    2025年

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  • Sandeep K. Singh,
  • Jonathan M. Collins

摘要

Microwave peptide synthesis offers significant advantages for peptide production in speed, efficiency, and overall purity. This chapter surveys key developments including the introduction of a wash-free methodology that has enabled 95% waste reduction in peptide synthesis at both research and production level solid-phase peptide synthesis (SPPS). Microwave SPPS is a widely used technique for R&D scale peptide synthesis with more recent expansion into larger scale current good manufacturing practice (cGMP).