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Cancer vaccine is an active immunotherapy approach that aims to stimulate the host’s immune responses toward specific targets on cancer cells, to direct their killing. Cancer cells commonly express aberrant cell surface glycosylation that support their immune evasion. Therefore, cancer glycosylation could be used as an efficient target for therapy. Lipid-based glyconanoparticles that express cancer glycosylation could mimic cancer cells and be used as therapeutic cancer vaccines. Here, we describe generation of biomimetic glyconanoparticles cancer vaccine based on porcine red blood cells that express cancer glycosylation containing the dietary nonhuman sialic acid N-glycolylneuraminic acid (Neu5Gc).

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Biomimetic Glyconanoparticle Nanoghost Vaccine Based on Red Blood Cells

  • 实验方案

  • 发表日期：

    2025年

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  • Nofar Israel,
  • Shani Leviatan Ben-Arye,
  • Andrea Perota,
  • Cesare Galli,
  • Vered Padler-Karavani

摘要

Cancer vaccine is an active immunotherapy approach that aims to stimulate the host’s immune responses toward specific targets on cancer cells, to direct their killing. Cancer cells commonly express aberrant cell surface glycosylation that support their immune evasion. Therefore, cancer glycosylation could be used as an efficient target for therapy. Lipid-based glyconanoparticles that express cancer glycosylation could mimic cancer cells and be used as therapeutic cancer vaccines. Here, we describe generation of biomimetic glyconanoparticles cancer vaccine based on porcine red blood cells that express cancer glycosylation containing the dietary nonhuman sialic acid N-glycolylneuraminic acid (Neu5Gc).