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Human embryonic kidney (HEK) cells’ low maintenance and quick proliferation make it an ideal target to begin cellular research. Current literature on the metabolomic changes in the fatty acids synthesis (FAS) process is sparse. Thus, inhibition of the pathway in extensively researched HEK cells would provide further insight into upregulation and downregulation of metabolites. Liquid chromatography-mass spectrometry allows for highly sensitive quantification and qualification to provide a comprehensive understanding of the metabolomic changes that can be applied to specialized cell types.

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Untargeted Metabolomics of Human Embryonic Kidney (HEK) Cell Line

  • 实验方案

  • 发表日期：

    2025年

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  • Xing Du,
  • Claudia Gomez,
  • Susanna Li,
  • Emily Dorairaj,
  • Samyak Jain,
  • Sanjoy K. Bhattacharya

摘要

Human embryonic kidney (HEK) cells’ low maintenance and quick proliferation make it an ideal target to begin cellular research. Current literature on the metabolomic changes in the fatty acids synthesis (FAS) process is sparse. Thus, inhibition of the pathway in extensively researched HEK cells would provide further insight into upregulation and downregulation of metabolites. Liquid chromatography-mass spectrometry allows for highly sensitive quantification and qualification to provide a comprehensive understanding of the metabolomic changes that can be applied to specialized cell types.