Outpatient neurosurgery has gained popularity, leading to enhanced patient satisfaction and cost savings. As a minimally invasive and time-efficient procedure, stereotactic brain biopsies are among the first cranial neurosurgical operations to be performed on an ambulatory basis. Most studies assessing the feasibility and safety of stereotactic brain biopsy in a day-case pathway have reported same-day discharge rates exceeding 90% and low complication rates. This chapter presents the argument that stereotactic brain biopsies can be safely performed in an outpatient setting in carefully selected patients. Widely adopting this process in neurosurgical centers does not compromise the quality of patient care and safety.