Stereotactic brain biopsy is one of the most commonly used procedures for obtaining brain tissues. This procedure is usually considered mini-invasive, quick, efficient, and safe, even if the results of the different studies are widely heterogeneous. Complications occurring after stereotactic brain biopsy are rare but have serious side effects. The mortality rate varies from 0% to 4%. The overall morbidity rate ranges from 1% to 13%. Most of the complications are revealed by the following symptoms: neurological impairment (transient or permanent), seizure, and unconsciousness. The symptomatic hemorrhage range varies from 0.9% to 8.6%, whereas in asymptomatic bleeding, the range may be as high as 59.8%. Corrective surgery is rare (<1%). The use of a grading scale can help to compare series from around the world. Future studies should establish a score that allows neurosurgeons to predict post-biopsy complications.