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Due to its similarity of skin anatomy and physiology, the pig appears to be a well-suited animal model for pre-clinical studies of skin analogue transplantations. The choice of the location of the skin defect and appropriate post-operative measures are essential for the protection of the transplanted graft. This protocol describes in detail a porcine skin transplantation model including peri- and postoperative measures taken to improve and refine the studies outcome.

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Transplantation of Autologous Dermo-Epidermal Skin Substitutes in a Pig Model

  • 实验方案

  • 发表日期：

    2025年

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  • Thea Fleischmann,
  • Flora Nicholls,
  • Miriam Lipiski,
  • Margarete Arras,
  • Nikola Cesarovic

摘要

Due to its similarity of skin anatomy and physiology, the pig appears to be a well-suited animal model for pre-clinical studies of skin analogue transplantations. The choice of the location of the skin defect and appropriate post-operative measures are essential for the protection of the transplanted graft. This protocol describes in detail a porcine skin transplantation model including peri- and postoperative measures taken to improve and refine the studies outcome.