Tissue engineering of skin is a field with high research activities and major importance for wound healing, especially following burn injuries. Animal models enable to test tissue engineered skin as well as different types of cells in a realistic setting. Although there are several challenges in working with pigs, it is a good model because of its similarity to the human skin and a comparable wound regeneration. Here, we explain our routinely used methods for using pig models to test tissue engineered skin in burn injuries.