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The Drosophila blood-brain barrier (BBB) has been shown to be largely analogous in structure and function to the vertebrate BBB. Thanks to the genetic tools available for this organism, Drosophila is uniquely suited to study BBB physiology and function, with high relevance for mammalian function. In this chapter, we discuss targeting strategies to specifically mark and manipulate BBB cells, how to test BBB barrier and transport integrity, and methods to isolate single BBB cells.

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Drosophila as a Model to Study the Blood-Brain Barrier

  • 实验方案

  • 发表日期：

    2025年

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  • Cameron R. Love,
  • Fahima Mayer,
  • Roland J. Bainton,
  • Brigitte Dauwalder

摘要

The Drosophila blood-brain barrier (BBB) has been shown to be largely analogous in structure and function to the vertebrate BBB. Thanks to the genetic tools available for this organism, Drosophila is uniquely suited to study BBB physiology and function, with high relevance for mammalian function. In this chapter, we discuss targeting strategies to specifically mark and manipulate BBB cells, how to test BBB barrier and transport integrity, and methods to isolate single BBB cells.