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Although the plaque reduction neutralization test (PRNT) is considered the reference for measuring neutralizing antibodies for Yellow fever virus (YFV), the micro-focus reduction neutralization test (mFRNT) presents many advantages including a higher throughput, a reduced incubation time, and allows the automatic foci count. So, here we describe a detailed mFRNT method that provides a faster neutralization test essential for non-clinical and clinical studies and vaccine design.

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Micro-Focus Reduction Neutralization Tests (mFRNT) for Neutralizing Antibody (Nab) Quantification Against Yellow Fever Virus

  • 实验方案

  • 发表日期：

    2025年

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  • Adriana de Souza Azevedo,
  • Nathalia dos Santos Alves

摘要

Although the plaque reduction neutralization test (PRNT) is considered the reference for measuring neutralizing antibodies for Yellow fever virus (YFV), the micro-focus reduction neutralization test (mFRNT) presents many advantages including a higher throughput, a reduced incubation time, and allows the automatic foci count. So, here we describe a detailed mFRNT method that provides a faster neutralization test essential for non-clinical and clinical studies and vaccine design.