Scholarlink

In this chapter, we provide examples of using genetically encoded voltage indicators (GEVIs) to monitor neuronal intercellular communications at the population level (hippocampus of CA1 region) and individual cell level (retinal ganglion cells). Providing an optical readout for voltage transients, GEVIs enable the reporting of synaptic activity, both activation and inhibition, from chemical and electrical synapses. With the added flexibility of restricting expression of the GEVI to distinct cell types, GEVIs are becoming a powerful tool for interrogating neuronal activity.

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Mapping Synaptic Activity at the Population and Cellular Levels with Genetically Encoded Voltage Indicators (GEVIs)

  • 实验方案

  • 发表日期：

    2025年

查看全文
  • Younginha Jung,
  • Ryuichi Nakajima,
  • Sung Min Ahn,
  • Nazarii Frankiv,
  • Haeun Lee,
  • Maesoon Im,
  • Yoon-Kyu Song,
  • Bradley J. Baker

摘要

In this chapter, we provide examples of using genetically encoded voltage indicators (GEVIs) to monitor neuronal intercellular communications at the population level (hippocampus of CA1 region) and individual cell level (retinal ganglion cells). Providing an optical readout for voltage transients, GEVIs enable the reporting of synaptic activity, both activation and inhibition, from chemical and electrical synapses. With the added flexibility of restricting expression of the GEVI to distinct cell types, GEVIs are becoming a powerful tool for interrogating neuronal activity.