Magnetic resonance imaging (MRI) allows the detection of signals from constituents of biological tissues. Hydrogen (1H) is the most widely used element from which spectra and images are detected due to its abundance and high sensitivity manifested in its gyromagnetic ratio. The high contrast for soft tissue has afforded scientists invaluable information about brain structure and function. Among many parameters determining the quality of MRI images, field strength is the most decisive one as it determines the signal strength in fMRI images. Considering the low inherent sensitivity of fMRI, high magnetic fields are the only way to enhance activation contrast of neurofunctional studies. This is why there has been a relentless drive toward higher field strength in human imaging raising it up to 11.7 T to date. The technology of 7-T has become more widely available in scanners with fMRI capability. Development of many technologies such as multichannel RF coils, strong and fast gradients, simultaneous slice excitation, and brain stimulation protocols have contributed to the expansion of fMRI as the method of choice for the study of whole brain function. In this chapter, challenges of high-field fMRI in human studies are discussed among which signal-to-noise, susceptibility artifacts, and multichannel RF coil designs are highlighted.