Scholarlink

The combination of fMRI with pharmacological interventions can provide valuable insights into how a given molecule impacts on the brain’s function. Pharmacological fMRI (pharmaco-fMRI) thus is of interest to both systems neuroscience to better understand the brain’s neurochemistry and to pharmacologists at several stages of compound development and validation. In this chapter, we describe the potential of pharmaco-fMRI in the context of systems neuroscience and neuropharmacology. We then discuss the limitations of using BOLD fMRI in the context of pharmacological interventions and highlight how to combine pharmaco-fMRI with other techniques to dissociate neuronal from non-neuronal contributions of a compound to the BOLD signal. In the last section, we outline key methodological considerations to optimize the design of pharmaco-fMRI experiments.

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Pharmacological Applications of fMRI

  • 实验方案

  • 发表日期：

    2025年

查看全文
  • David Meder,
  • Oliver J. Hulme,
  • Hartwig R. Siebner

摘要

The combination of fMRI with pharmacological interventions can provide valuable insights into how a given molecule impacts on the brain’s function. Pharmacological fMRI (pharmaco-fMRI) thus is of interest to both systems neuroscience to better understand the brain’s neurochemistry and to pharmacologists at several stages of compound development and validation. In this chapter, we describe the potential of pharmaco-fMRI in the context of systems neuroscience and neuropharmacology. We then discuss the limitations of using BOLD fMRI in the context of pharmacological interventions and highlight how to combine pharmaco-fMRI with other techniques to dissociate neuronal from non-neuronal contributions of a compound to the BOLD signal. In the last section, we outline key methodological considerations to optimize the design of pharmaco-fMRI experiments.